Gut microbiota and health

Panax ginseng and Polygonum cuspidatum reduce atherosclerosis in mice by modulating gut microbiota composition and metabolite profiles, offering mechanistic insights for cardiovascular disease.

Drug-microbiome-drug interaction study reveals how COMT inhibitors used with levodopa alter gut bacteria and affect medication metabolism in Parkinson's patients.

PALM, a quasi-Poisson regression framework, enables fast and reliable association discovery in large-scale microbiome studies by controlling false discovery rates and improving power.

Analysis of ethical concerns in human microbiome research, proposing collaborative frameworks to address geographic bias, community exclusion, and underrepresentation of global researchers.

Metagenomic analysis reveals distinct faecal microbiome structures in wild versus domesticated pigs, identifying carbohydrate-degrading taxa shaped by diet and lifestyle for probiotic development.

Systematic review confirms periodontitis increases acute myocardial infarction risk by 84%, with radiographic bone loss showing strongest association independent of traditional cardiovascular factors.

Study of 12,519 individuals reveals how human genetic variants control oral microbiome composition and link to tooth decay risk through salivary enzyme abundance.

Review examining how microbial fermentation converts plant polyphenols into bioavailable metabolites that enhance gut health and systemic immune function through selective microbiota modulation.

Dysbiosis-induced microbial metabolic reprogramming drives metabolic disease through alterations in lipid, glucose, amino acid, and uric acid metabolism.

Standardized scoring system for murine colitis models in preclinical IBD research, addressing variability across laboratory assessments.

Population density stress alters fecal microbiota and metabolites in Qinghai-Tibet Plateau root voles, reducing beneficial bacteria and essential amino acids while elevating stress biomarkers and.

Population-based study linking 8-year antibiotic prescription data with fecal metagenomes in 14,979 adults to characterize associations between oral antibiotic use and gut microbiome composition.

Age-associated cognitive decline driven by impaired gut-brain interoceptive signalling through microbial metabolite-induced vagal dysfunction and hippocampal neuronal dysfunction.

Ecological network balance index quantifies positive and negative microbial interactions as a marker of dysbiosis, differentiating health from disease states with mechanistic grounding.

Nasal microbiome composition shows modest but significant associations with epigenomic variation among adolescents, warranting investigation of environmental and developmental factors.

Study reveals how the oral pathogen Porphyromonas gingivalis persists below critical population thresholds through stochastic processes and facilitation by early colonizers like Veillonella parvula.

How maternal and infant gut microbiomes shape pregnancy outcomes, immune development, and long-term health during the critical first 1000 days of life.

Randomized trial demonstrates probiotic supplementation significantly increases total antioxidant capacity in open-heart surgery patients over two-week perioperative period.

Multi-omics study reveals how the microbial metabolite phenyllactic acid drives mitochondrial dysfunction and intestinal barrier damage in experimental autoimmune encephalomyelitis through OXPHOS.

Longitudinal study identifies distinct gut microbiota alterations in Hirschsprung disease patients, revealing bacterial markers for postoperative enterocolitis risk.