Focal Interest
Focal Interest

Fluorine in Organic Chemistry

External reference: https://openalex.org/T10947

  1. DOM forms PFAS nanoclusters and lowers phytotoxicity
    In situ AFM reveals DOM-induced PFAS nanoclustering reduces phytotoxicity through altered bioaccessibility, challenging molecular dispersal-based risk paradigms.
  2. Pentafluoroethylation of styrenes expanded by a sulfoximine reagent
    Synthesis and photocatalytic application of pentafluoroethyl sulfoximine for difunctionalization of styrenes via concurrent C-C and C-heteroatom bond formation under mild conditions.
  3. Pyridinium catalysis enables stereoselective 2-deoxy-2-fluoroglycoside assembly
    Pyridinium-catalyzed stereoselective synthesis of 2-deoxy-2-fluoroglycosides via syn-addition to 2-fluoroglycals with mechanistic insights from NMR and DFT studies.
  4. Photoredox method enables deoxytrifluoromethoxylation of phenols
    Photoredox-catalyzed deoxytrifluoromethoxylation installs OCF3 groups on phenols via in situ difluorophosgene generation and aryl carbonofluoridate activation.
  5. Metal-free trifluoromethylalkynylation of unsaturated peptides
    Metal-free concurrent trifluoromethyl and alkynyl installation on unsaturated peptides under mild conditions, enabling rapid access to multifunctional peptide scaffolds for medicinal chemistry.