Fluorine in Organic Chemistry

Photo- and acid-mediated repurposing of Grushin's reagent enables efficient difluoromethylation of alcohols, saccharides, and bioactive molecules, generating antifungal leads.

A fluorescence sensor array combined with deep learning quantifies multiple PFAS contaminants in water samples simultaneously, providing rapid screening for environmental monitoring.

Organocatalytic cross-dehydrogenative coupling of tetrahydroisoquinolines with fluoronitromethane using Rose Bengal and green LED irradiation for sustainable fluorinated compound synthesis.

Metal-free organophotoredox catalysis enables efficient alkylation of vinylsulfur pentafluoride to synthesize SF5-containing aliphatic molecules under mild conditions with broad functional group.

F6H8, an ophthalmic treatment for dry eye, produces PFAS-like metabolites and triggers broad metabolic disruption in human hepatocytes, raising long-term safety concerns.

Chemical recycling method converts hydrofluorocarbons into usable fluoride sources through transfer fluorination, enabling synthesis of diverse fluorinated molecules at industrial scale.

Photocatalytic metal-free synthesis of α-trifluoromethyl amidines and imidates using isocyanides and trifluoroacetylsilanes, with mechanistic insights from DFT studies.

Chemiresistive sensor with molecularly imprinted polymer and fluorine-fluorine interactions achieves 1.3 ng·L⁻¹ detection of PFOS in environmental samples with validated accuracy.

Study measuring per- and polyfluoroalkyl substances in Croatian eggs across production systems, identifying home-produced eggs as significantly more contaminated and young children as most vulnerable.

New protocol for thio-Belluš-Claisen rearrangement with difluoroketene using desilylative β-elimination. Electronic effects on substrate promotion of reactivity.

PFOS induces neurodegeneration in basal forebrain cholinergic neurons through oxidative stress, PGE2 dysregulation, and NGF pathway disruption; T3 treatment offers partial neuroprotection.

Synthesis and characterization of novel [PdF3(XeF2)3]+ and [PtF3(XeF2)3]+ adduct cations represents a new class of XeF2 coordination compounds to fluoridometal cations.

Modular synthesis of CF3/CHF2-substituted dihydroquinoline sulfonyl fluorides via [4+2] cycloaddition and sulfur(VI) fluoride exchange without transition metal catalysis.

Synthesis of polyfluorinated diketoesters and tetraketones from perfluorinated dicarboxylic acid esters and alkyl ketones, with mechanistic investigation via MP2 calculations.

Study reveals molecular mechanisms linking PFOA exposure to bladder cancer through integrative toxicogenomics and gene expression analysis, identifying key transcriptional signatures for cancer.

Electrochemical degradation of PFOA enhanced by nitrogen-containing compounds with lone-pair electrons; mechanisms involve direct electron transfer and reactive nitrogen species generation.

Stereochemical assignment of N,N-dialkyl trifluoroacetamides using integrated analysis of through-space 1H···19F spin-spin couplings and aromatic solvent-induced shifts in 1H-NMR spectroscopy.

Tiered PFAS fingerprinting framework for source differentiation using targeted analytics, diagnostic ratios, isomer patterns, and geospatial analysis in complex industrial groundwater settings.

Novel sequential perfluoroalkylation and defluoroamination of indoles via sulfinate-derived radicals and HMDS-mediated C-F cleavage, yielding α-trifluoromethylated amines in up to 80% yield.

Visible-light photocatalytic defluorination of PFAS using stabilized porphyrin radicals achieving near-complete conversion without additives.