Analytical chemistry methods development

RP-HPLC method for simultaneous quantification of metoprolol and enalapril maleate using environmentally sustainable approach with recovery rates of 98–102% and validation per ICH criteria.

Composite cryogel column with molecularly imprinted microparticles achieves selective L-phenylalanine separation with 39.40 mg/g adsorption capacity and reusability.

Adding trace ethylene to nitrogen carrier gas in GC-MS increases sensitivity 20-fold while maintaining 70 eV electron-ionization spectral patterns compatible with existing reference libraries.

Novel radial flow stream splitting HPLC columns reduce analysis time by 40 percent while maintaining quantitative accuracy for pharmaceutical drug testing.

Miniaturized extraction selectively enriches trace polycyclic aromatics in mineral oils, improving detection of genotoxic compounds masked by abundant alkylated aromatics in complex mixtures.

Static headspace sampling with cryogenic modulation GC×GC-TOFMS enables comprehensive volatile and chiral analysis of citrus essential oils, eliminating solvents while improving detectability for.

Light-driven cellulose-azobenzene sorbent for amphetamine extraction with UV-triggered 90% desorption efficiency and validated HPLC-UV method.

Interlaboratory validated HPLC-ELSD method for accurate polysorbate 80 quantification in monoclonal antibody formulations with robust performance across diverse laboratory settings.