Analytical Chemistry and Chromatography

Chiral mesoporous silica carriers enhance celecoxib bioavailability and anti-inflammatory activity through hydrogen bonding and crystal-to-amorphous phase conversion.

RP-HPLC method for simultaneous quantification of metoprolol and enalapril maleate using environmentally sustainable approach with recovery rates of 98–102% and validation per ICH criteria.

Composite cryogel column with molecularly imprinted microparticles achieves selective L-phenylalanine separation with 39.40 mg/g adsorption capacity and reusability.

HILIC-DIA-MS workflow for targeted and untargeted analysis of polar peptides and taste-relevant compounds in foods including cheese, ham, and fermented products.

Adding trace ethylene to nitrogen carrier gas in GC-MS increases sensitivity 20-fold while maintaining 70 eV electron-ionization spectral patterns compatible with existing reference libraries.

Systematic evaluation of derivatization agents for LC-MS amino acid analysis identifies isoquinoline-6-carboxylic acid NHS ester as optimal, achieving nanomolar sensitivity and long-term stability.

Novel radial flow stream splitting HPLC columns reduce analysis time by 40 percent while maintaining quantitative accuracy for pharmaceutical drug testing.

Hydrogen-based GC-IMS combined with machine learning enables rapid, sustainable classification of cocoa by geographic origin without sample preparation.

Miniaturized extraction selectively enriches trace polycyclic aromatics in mineral oils, improving detection of genotoxic compounds masked by abundant alkylated aromatics in complex mixtures.

Stability-indicating HPTLC method validated for gentamicin sulphate quantification in ointments, requiring no sample extraction and showing high linearity and sensitivity.

Hyperbranched polystyrene exhibits nonuniversal exclusion-to-adsorption transitions in chromatography, governed by branching density and fractal dimension, diverging from linear polymer behavior.

Dual-cyclodextrin systems in electrokinetic chromatography enhance chiral resolution for pharmaceutical, biological, and environmental analyses with model-based optimization.

Static headspace sampling with cryogenic modulation GC×GC-TOFMS enables comprehensive volatile and chiral analysis of citrus essential oils, eliminating solvents while improving detectability for.

Light-driven cellulose-azobenzene sorbent for amphetamine extraction with UV-triggered 90% desorption efficiency and validated HPLC-UV method.

RP-HPLC method development and validation for simultaneous determination of caffeine, eugenol, and zingerone in Ashwagandha green tea using Design of Experiments and ICH guidelines.

Development and ICH-compliant validation of a stability-indicating RP-HPLC method for quantitative determination of dexlansoprazole in bulk and capsule forms.

Interlaboratory validated HPLC-ELSD method for accurate polysorbate 80 quantification in monoclonal antibody formulations with robust performance across diverse laboratory settings.

Ultrathin 2D nanosheets from exfoliated chiral ionic organic crystals enable high-resolution gas chromatography with exceptional enantioselectivity for pharmaceutical compound separation.

AQbD-based UHPLC-ToF-MS method for simultaneous analysis of synthetic peptides, incorporating design space definition and greenness assessment for robust analytical characterization.

MALDI-TIMS-MS platform with chiral derivatization for enantiomeric discrimination of α-hydroxy acids in tumor tissues and food samples with sensitivity to 5.8% enantiomeric ratios.