Focal Interest
Focal Interest

Synthesis and Characterization of Pyrroles

External reference: https://openalex.org/T12562

  1. Electron-withdrawing groups enable thio-Belluš–Claisen rearrangement with difluoroketene
    New protocol for thio-Belluš-Claisen rearrangement with difluoroketene using desilylative β-elimination. Electronic effects on substrate promotion of reactivity.
  2. THF increased yields of polyfluorinated tetraketones
    Synthesis of polyfluorinated diketoesters and tetraketones from perfluorinated dicarboxylic acid esters and alkyl ketones, with mechanistic investigation via MP2 calculations.
  3. Metal-free trifluoromethylalkynylation of unsaturated peptides
    Metal-free concurrent trifluoromethyl and alkynyl installation on unsaturated peptides under mild conditions, enabling rapid access to multifunctional peptide scaffolds for medicinal chemistry.