Focal Interest
Focal Interest

Stereoselectivity

  1. Desymmetrization method forms N–N atropisomers with multiple stereocenters
    Asymmetric Michael addition constructs N-N atropisomers from indole-derived maleimides with simultaneous generation of multiple stereocenters, achieving 99% yield and exceptional stereoselectivity.
  2. Dual cyclodextrin systems support chiral separations in EKC
    Dual-cyclodextrin systems in electrokinetic chromatography enhance chiral resolution for pharmaceutical, biological, and environmental analyses with model-based optimization.
  3. Pyridinium catalysis enables stereoselective 2-deoxy-2-fluoroglycoside assembly
    Pyridinium-catalyzed stereoselective synthesis of 2-deoxy-2-fluoroglycosides via syn-addition to 2-fluoroglycals with mechanistic insights from NMR and DFT studies.