Sarcoma Diagnosis and Treatment

First documented case of synovial chondromatosis causing external auditory canal stenosis with atypical inferior joint space involvement treated via combined open and endoscopic surgery.

Phase 1b/2 trial of olutasidenib in IDH1-mutated chondrosarcoma shows disease control without dose-limiting toxicities; 52% stable disease rate in recurrent/metastatic disease.

Case report demonstrates promising response to pembrolizumab and pazopanib combination therapy in metastatic dedifferentiated chondrosarcoma, highlighting emerging systemic treatment options.

Quantitative nuclear morphometry combined with genetic analysis reveals morphological markers of recurrence risk in chordoma, offering potential for improved prognostic assessment.

Surgical resection of chemoresistant FUS::TFCP2-positive rhabdomyosarcoma in an 11-year-old with mandibular tumor. Case report demonstrates radical surgery success after failed chemotherapy.

Case report of mesenchymal chondrosarcoma in a 13-year-old with HEY1::NCOA2 fusion treated with multimodal therapy including sirolimus targeting mTOR pathway.

Myoepithelial tumor with EWSR1-PBX3 fusion in rib and soft tissue: molecular and clinicopathological findings with disease-free outcome.

En bloc resection of proximal fibular giant cell tumours in young patients achieves 85% complete nerve recovery with no recurrence and excellent knee stability outcomes at one-year follow-up.

Surgical techniques for proximal fibular tumor resection with nerve preservation and tibial reconstruction to maintain knee stability and function.

Multi-omics analysis identifies HSPA8, LMNA, and SERPINH1 as angiogenesis and integrated stress response biomarkers in chondrosarcoma with therapeutic potential.