Focal Interest
Focal Interest

Reagent

  1. Trifluoromethyl copper complexes were repurposed for saccharide difluoromethylation
    Photo- and acid-mediated repurposing of Grushin's reagent enables efficient difluoromethylation of alcohols, saccharides, and bioactive molecules, generating antifungal leads.
  2. P-H bond pKa values of triorganophosphonium salts measured in toluene
    Experimental pKa values of P-H bonds in triorganophosphonium bistriflimides determined in toluene using spectroscopy and DFT, providing guidelines for catalytic phosphine generation.
  3. Method distinguishes chiral α-hydroxy acids in complex samples
    MALDI-TIMS-MS platform with chiral derivatization for enantiomeric discrimination of α-hydroxy acids in tumor tissues and food samples with sensitivity to 5.8% enantiomeric ratios.
  4. 2-Lithiomethylindoles enable diverse 2-functionalized indoles
    Optimized α-lithiation protocol for 1,2-dimethylindoles enables efficient C2-functionalization via diverse electrophile trapping in deep eutectic solvents under air-tolerant conditions.
  5. Pentafluoroethylation of styrenes expanded by a sulfoximine reagent
    Synthesis and photocatalytic application of pentafluoroethyl sulfoximine for difunctionalization of styrenes via concurrent C-C and C-heteroatom bond formation under mild conditions.
  6. Metal-free trifluoromethylalkynylation of unsaturated peptides
    Metal-free concurrent trifluoromethyl and alkynyl installation on unsaturated peptides under mild conditions, enabling rapid access to multifunctional peptide scaffolds for medicinal chemistry.