Focal Interest
Focal Interest

Randomized controlled trial

  1. Review highlights key biases in observational studies
    A critical examination of validity threats in observational studies, including confounding, selection bias, time-varying confounding, measurement error, and missing data handling strategies.
  2. 3D interlocking miniplates improved bone density in mandibular fractures
    Split-mouth trial shows 3D interlocking miniplates produce faster bone healing and better nerve recovery than conventional plates for mandibular fractures near the mental foramen.
  3. Buteyko breathing improved asthma control, fatigue, and exercise capacity
    Randomized trial shows Buteyko breathing technique improves exercise capacity, reduces fatigue, and enhances asthma control as a safe, low-cost adjunct to standard asthma treatment.
  4. Virtual reality exercise improved college students’ mood states
    8-week trial shows virtual reality exercise reduces tension, anger, and depression while increasing vigor more effectively than traditional aerobic exercise in college students.
  5. No evidence of increased gaming-related problems with long-term use of a video game therapeutic: Exploratory endpoint findings from a randomized controlled trial
    Long-term use of a video game therapeutic for depression showed no increase in gaming-related problems, with deterioration rates low across all study arms.
  6. RIRS and mini-PCNL were similarly effective for high-density pediatric kidney stones
    Prospective randomized trial comparing flexible ureterorenoscopy and mini-percutaneous nephrolithotomy for pediatric renal pelvic stones under 2 cm with high density, showing comparable efficacy.
  7. Legal awareness intervention reduced anxiety in vocational students
    Digital legal awareness intervention reduces anxiety among Chinese vocational students through enhanced positive coping strategies. Theory-based interactive multimedia program shows moderate to.
  8. Hypodermoclysis appears generally safe in advanced cancer
    Hypodermoclysis shows favorable safety and feasibility for hydration in advanced cancer patients receiving palliative care, with mild complications in 17% of cases and no consistent survival benefits.
  9. Remote group exercise increased activity in postpartum women
    Remote group-based exercise intervention increases moderate-to-vigorous physical activity and enhances sense of coherence and self-efficacy in postpartum women during 8-week trial.
  10. MuST AKT was feasible and acceptable in a pilot trial
    MuST AKT pilot trial tests structured intervention to increase living donor kidney transplants through multidisciplinary support and social network engagement.
  11. Adjusted light color temperature lowered stress and anxiety
    Randomized controlled trial examining medium-warm white light effects on stress, anxiety, and psychological well-being in high-risk pregnant women undergoing non-stress testing procedures.
  12. Probiotic supplementation and postoperative antioxidant response in patients undergoing open‑heart surgery: a randomized controlled trial.
    Randomized trial demonstrates probiotic supplementation significantly increases total antioxidant capacity in open-heart surgery patients over two-week perioperative period.
  13. Family navigation improved early intervention access
    Family navigation intervention significantly increases early intervention services utilization among low-income, racially diverse children with developmental delays in a randomized controlled trial.
  14. Critically ill COVID-19 trial participants often lacked understanding
    Qualitative study examining COVID-19 ICU patients' experiences in REMAP-CAP Japan trial, revealing significant barriers to informed consent comprehension in critical care settings.
  15. FMT with immunotherapy showed activity in NSCLC and melanoma
    Phase 2 trial: donor FMT plus first-line ICI in NSCLC and melanoma showed high ORRs and implicates loss of specific bacterial taxa in association with response.