Focal Interest
Focal Interest

Proliferating cell nuclear antigen

  1. PAF15-PCNA exhaustion limits strand-specific DNA replication control
    Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
  2. AOH1996 remained the most active PCNA inhibitor analog
    Synthesis and anticancer evaluation of PCNA inhibitor AOH1996 analogs in MCF-7 and U87 cancer cell cultures with SAR analysis and ADMET prediction
  3. CTF18-RFC structure reveals how it binds PCNA
    Cryo-EM structure of human CTF18–RFC clamp loader bound to PCNA reveals autoinhibited conformation and unique structural features governing leading strand synthesis.