Focal Interest
Focal Interest

Mutation

  1. Compensatory mutations showed limited effect on MDR/RR-TB clustering
    Population-based whole-genome sequencing study of 206 MDR/RR-TB isolates in China reveals compensatory mutations have limited impact on transmission clustering.
  2. Mitotic repair pathway drives chromoanasynthesis
    Study reveals mitotic microhomology-mediated break-induced replication drives chromoanasynthesis, a complex chromosomal rearrangement mechanism in cancer and congenital disorders.
  3. Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks
    Tel1-mediated negative feedback propagates locally to reshape genome-wide meiotic DSB patterns in yeast, demonstrating how localized regulation drives emergent patterning.