Focal Interest
Focal Interest

Microtubule and mitosis dynamics

External reference: https://openalex.org/T10492

  1. PAF15-PCNA exhaustion limits strand-specific DNA replication control
    Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
  2. Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks
    Tel1-mediated negative feedback propagates locally to reshape genome-wide meiotic DSB patterns in yeast, demonstrating how localized regulation drives emergent patterning.
  3. CTF18-RFC structure reveals how it binds PCNA
    Cryo-EM structure of human CTF18–RFC clamp loader bound to PCNA reveals autoinhibited conformation and unique structural features governing leading strand synthesis.
  4. Bora links Aurora-A activation to PLK1 recognition
    Structural analysis revealing how the intrinsically disordered protein Bora bridges Aurora-A kinase and PLK1 substrate recognition through phosphorylation-dependent mechanisms during mitotic entry.
  5. Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction
    Whole-genome sequencing of Drosophila reveals chromosome-specific recombination patterns in meiotic nondisjunction, with metacentric chromosome 2 showing reduced recombination.