Focal Interest
Focal Interest

Metagenomics

  1. Fast and reliable association discovery in large-scale microbiome studies and meta-analyses using PALM
    PALM, a quasi-Poisson regression framework, enables fast and reliable association discovery in large-scale microbiome studies by controlling false discovery rates and improving power.
  2. Wild boar and domestic pig gut microbes differ by diet and lifestyle
    Metagenomic analysis reveals distinct faecal microbiome structures in wild versus domesticated pigs, identifying carbohydrate-degrading taxa shaped by diet and lifestyle for probiotic development.
  3. Human and bacterial genetics shape oral microbiome variation
    Study of 12,519 individuals reveals how human genetic variants control oral microbiome composition and link to tooth decay risk through salivary enzyme abundance.
  4. Ecological network balance index distinguishes healthy and dysbiotic gut states
    Ecological network balance index quantifies positive and negative microbial interactions as a marker of dysbiosis, differentiating health from disease states with mechanistic grounding.
  5. High-resolution spatial transcriptomics maps gut microbiome biogeography
    Spatial transcriptomics method combining enzymatic polyadenylation and RNA sequencing for high-resolution mapping of host-gut microbiome interactions and microbial biogeography.
  6. Baby-to-baby transmission shapes the infant gut microbiome
    Study reveals how baby-to-baby microbiome transmission in nurseries substantially shapes infant gut health during the first year, complementing maternal microbial inheritance.