Focal Interest
Focal Interest

Metabolomics and Mass Spectrometry Studies

External reference: https://openalex.org/T10836

  1. Functional groups strongly affect amino acid LC-MS derivatization
    Systematic evaluation of derivatization agents for LC-MS amino acid analysis identifies isoquinoline-6-carboxylic acid NHS ester as optimal, achieving nanomolar sensitivity and long-term stability.
  2. Targeted Metabolomic Profiling of Carnitines Reveals Diagnostic Candidates in Postpartum Cardiomyopathy
    Targeted metabolomics study identifies altered carnitine profiles in postpartum cardiomyopathy, with acetylcarnitine and related species as potential diagnostic biomarker candidates.
  3. Urine metabolomics showed distinct patterns across paediatric TB states
    Urine metabolomics via NMR spectroscopy shows promise for early diagnosis of paediatric tuberculosis, achieving 97% accuracy in distinguishing active TB from latent infection.
  4. Method distinguishes chiral α-hydroxy acids in complex samples
    MALDI-TIMS-MS platform with chiral derivatization for enantiomeric discrimination of α-hydroxy acids in tumor tissues and food samples with sensitivity to 5.8% enantiomeric ratios.