Focal Interest
Focal Interest

Intracellular

  1. F6H8 altered human liver cell metabolism and produced a PFAS-like metabolite
    F6H8, an ophthalmic treatment for dry eye, produces PFAS-like metabolites and triggers broad metabolic disruption in human hepatocytes, raising long-term safety concerns.
  2. Neuronal alpha-synuclein clearance is impaired and transfer to microglia increases
    Neurons with impaired α-synuclein clearance transfer aggregates to microglia via tunneling nanotubes. Study reveals dysfunctional neuronal autophagy drives intercellular aggregate transfer and.
  3. Craniofacial fibrous dysplasia osteoblasts show altered bone homeostasis
    Study characterizes osteoblasts from craniofacial fibrous dysplasia, revealing elevated cAMP, impaired mineralization, and suppressed osteoclastogenesis contributing to abnormal bone homeostasis.