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Indoles converted to α-perfluoroalkylamino derivatives under mild conditions
Novel sequential perfluoroalkylation and defluoroamination of indoles via sulfinate-derived radicals and HMDS-mediated C-F cleavage, yielding α-trifluoromethylated amines in up to 80% yield.
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2-Lithiomethylindoles enable diverse 2-functionalized indoles
Optimized α-lithiation protocol for 1,2-dimethylindoles enables efficient C2-functionalization via diverse electrophile trapping in deep eutectic solvents under air-tolerant conditions.
