Focal Interest
Focal Interest

Homologous recombination

  1. Talazoparib resistance in triple-negative breast cancer linked to BRN2 and SHLD2
    Study identifies BRN2-mediated and SHLD2-related resistance to talazoparib in BRCA-mutant breast cancer, proposing combination therapy approaches to improve neoadjuvant treatment outcomes.
  2. Complex chromosome 6 inversions produced recombinant offspring
    Complex paracentric inversion of chromosome 6q with multiple sequential inversions generated recombinant chromosomes in offspring, challenging traditional reproductive risk assumptions.
  3. Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks
    Tel1-mediated negative feedback propagates locally to reshape genome-wide meiotic DSB patterns in yeast, demonstrating how localized regulation drives emergent patterning.
  4. Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction
    Whole-genome sequencing of Drosophila reveals chromosome-specific recombination patterns in meiotic nondisjunction, with metacentric chromosome 2 showing reduced recombination.