Focal Interest
Focal Interest

Genome instability

  1. SFPQ helps protect repeat DNA from R-loop damage
    SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.
  2. A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability
    Integrated analytical framework reveals 7.13-fold enrichment of doublet base substitutions at inversion breakpoints in chronic low-dose radiation exposure of human cells.