Focal Interest
Focal Interest

Genetics, Aging, and Longevity in Model Organisms

External reference: https://openalex.org/T10676

  1. Gompertz parameter changes in C. elegans reflect decrepitude expansion
    Study reinterprets Gompertz mortality parameters, showing lifespan extensions reflect expanded decrepitude rather than slowed biological ageing in C. elegans.
  2. Authors argue longevity research has an ethical case
    Ethical case for longevity science grounded in autonomy and self-ownership rather than consequences alone; addresses philosophical and societal objections to aging research.
  3. Skewness and kurtosis explain much of lifespan disparity
    Analysis of 41 countries shows how skewness and kurtosis of age-at-death distributions explain mortality compression trends and lifespan disparity patterns from 1751–2019.
  4. A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric Proteins
    Development and validation of a bioinformatics pipeline for analyzing HT-SELEX data to characterize DNA-binding properties of telomeric proteins in human and C. elegans.
  5. C. elegans lifespan is limited by different competing causes of death
    Study reveals how multiple age-related pathologies interact hierarchically to determine lifespan in C. elegans, showing bacterial infection and neoplasia mask or unmask each other's effects on.
  6. Review highlights histone marks in C. elegans embryonic cell cycle
    Explore histone modifications during C. elegans embryonic cell division, examining H4K20me1, H3S10ph, and other epigenetic marks that regulate chromatin dynamics and mitotic progression.
  7. Centenarian cohort profile described in Colombia
    Colombian centenarian cohort baseline study characterizing health status and aging determinants to advance understanding of extreme longevity mechanisms.