Focal Interest
Focal Interest

DNA

  1. Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair
    Study reveals ATF4 regulates DNA repair genes critical for development of expanded upper cortical layers in mammalian brains, enabling progenitor survival under replicative stress.
  2. Mycobacterial gyrase inhibition depends on DNA topology
    Study reveals that antibacterial drugs inhibit different gyrase-mediated catalytic activities at varying concentrations, with DNA topology modulating drug potency beyond DNA cleavage mechanisms.
  3. A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric Proteins
    Development and validation of a bioinformatics pipeline for analyzing HT-SELEX data to characterize DNA-binding properties of telomeric proteins in human and C. elegans.
  4. Mitotic repair pathway drives chromoanasynthesis
    Study reveals mitotic microhomology-mediated break-induced replication drives chromoanasynthesis, a complex chromosomal rearrangement mechanism in cancer and congenital disorders.
  5. Shotgun DNA sequencing evidence: Sample-specific and unknown genotyping error probabilities
    Extension of the wgsLR statistical model for shotgun DNA sequencing in forensics, accommodating asymmetric and unknown genotyping error probabilities through profile likelihood and Bayesian methods.
  6. Human Pol-PCNA binds DNA in an unexpected extra site
    Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.
  7. SFPQ helps protect repeat DNA from R-loop damage
    SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.
  8. dd-cfDNA tracks kidney rejection activity across the continuum
    Donor-derived cell-free DNA quantifies kidney allograft rejection non-invasively across histopathological spectra, with combined scoring optimizing detection of microvascular and antibody-mediated.
  9. Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks
    Tel1-mediated negative feedback propagates locally to reshape genome-wide meiotic DSB patterns in yeast, demonstrating how localized regulation drives emergent patterning.
  10. Low-energy electrons selectively cleave DNA bonds in films
    Study reveals energy-dependent selective bond cleavage in DNA films exposed to low-energy electrons using XPS analysis, showing preferential damage to N-glycosidic and sugar-phosphate bonds.
  11. SNP profile completeness varied, but DNA metrics only partly predicted it
    Large-scale analysis of DNA quantification metrics and SNP sequencing performance in unidentified human remains shows robust applicability for forensic identification despite moderate predictability.
  12. A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability
    Integrated analytical framework reveals 7.13-fold enrichment of doublet base substitutions at inversion breakpoints in chronic low-dose radiation exposure of human cells.