Focal Interest
Focal Interest

DNA repair

  1. DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
    Study reveals how elevated DNA damage and impaired repair mechanisms drive selective vulnerability of cortical neurons in MS and neuroinflammation.
  2. Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair
    Study reveals ATF4 regulates DNA repair genes critical for development of expanded upper cortical layers in mammalian brains, enabling progenitor survival under replicative stress.
  3. A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability
    Integrated analytical framework reveals 7.13-fold enrichment of doublet base substitutions at inversion breakpoints in chronic low-dose radiation exposure of human cells.