Focal Interest
Focal Interest

DNA polymerase

  1. PAF15-PCNA exhaustion limits strand-specific DNA replication control
    Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
  2. Human Pol-PCNA binds DNA in an unexpected extra site
    Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.
  3. CTF18-RFC structure reveals how it binds PCNA
    Cryo-EM structure of human CTF18–RFC clamp loader bound to PCNA reveals autoinhibited conformation and unique structural features governing leading strand synthesis.