Focal Interest
Focal Interest

DNA damage

  1. DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
    Study reveals how elevated DNA damage and impaired repair mechanisms drive selective vulnerability of cortical neurons in MS and neuroinflammation.
  2. Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair
    Study reveals ATF4 regulates DNA repair genes critical for development of expanded upper cortical layers in mammalian brains, enabling progenitor survival under replicative stress.
  3. A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric Proteins
    Development and validation of a bioinformatics pipeline for analyzing HT-SELEX data to characterize DNA-binding properties of telomeric proteins in human and C. elegans.
  4. DBSCAN estimates DNA damage yields from ion beam quality
    DBSCAN algorithm predicts DNA damage yields and assesses beam quality for proton and carbon ion irradiation with a novel Quality of Beam metric for radiotherapy.
  5. Low-energy electrons selectively cleave DNA bonds in films
    Study reveals energy-dependent selective bond cleavage in DNA films exposed to low-energy electrons using XPS analysis, showing preferential damage to N-glycosidic and sugar-phosphate bonds.
  6. A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability
    Integrated analytical framework reveals 7.13-fold enrichment of doublet base substitutions at inversion breakpoints in chronic low-dose radiation exposure of human cells.