Focal Interest
Focal Interest

Desymmetrization

  1. Desymmetrization method forms N–N atropisomers with multiple stereocenters
    Asymmetric Michael addition constructs N-N atropisomers from indole-derived maleimides with simultaneous generation of multiple stereocenters, achieving 99% yield and exceptional stereoselectivity.
  2. Oxoammonium catalysis enables enantioselective desymmetrization of meso-pyrrolidines
    Oxoammonium-catalyzed desymmetrization of meso-pyrrolidines via enantioselective hydride transfer with over 90% ee, featuring mechanistic insights from isolated intermediates.