Focal Interest
Focal Interest

Derivatization

  1. Functional groups strongly affect amino acid LC-MS derivatization
    Systematic evaluation of derivatization agents for LC-MS amino acid analysis identifies isoquinoline-6-carboxylic acid NHS ester as optimal, achieving nanomolar sensitivity and long-term stability.
  2. Oxoammonium catalysis enables enantioselective desymmetrization of meso-pyrrolidines
    Oxoammonium-catalyzed desymmetrization of meso-pyrrolidines via enantioselective hydride transfer with over 90% ee, featuring mechanistic insights from isolated intermediates.
  3. Method distinguishes chiral α-hydroxy acids in complex samples
    MALDI-TIMS-MS platform with chiral derivatization for enantiomeric discrimination of α-hydroxy acids in tumor tissues and food samples with sensitivity to 5.8% enantiomeric ratios.