Focal Interest
Focal Interest

Cognitive decline

  1. Neurodegeneration, Oxidative Stress, NGF/TrkA/P75NTR, and PGE2 Dysregulation Induced by PFOS Single and Repeated Treatment: Partial Protection by T3 and Other Therapeutic Approaches
    PFOS induces neurodegeneration in basal forebrain cholinergic neurons through oxidative stress, PGE2 dysregulation, and NGF pathway disruption; T3 treatment offers partial neuroprotection.
  2. Gut-brain signaling dysfunction is linked to age-related memory decline
    Age-associated cognitive decline driven by impaired gut-brain interoceptive signalling through microbial metabolite-induced vagal dysfunction and hippocampal neuronal dysfunction.
  3. Connectivity pattern predicted cognitive decline in type 2 diabetes
    Brain imaging reveals how emotional conflict monitoring predicts cognitive decline in type 2 diabetes, using machine learning to identify early warning signs through functional connectivity patterns.