Focal Interest
Focal Interest

Chromatin

  1. Review highlights histone marks in C. elegans embryonic cell cycle
    Explore histone modifications during C. elegans embryonic cell division, examining H4K20me1, H3S10ph, and other epigenetic marks that regulate chromatin dynamics and mitotic progression.
  2. SFPQ helps protect repeat DNA from R-loop damage
    SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.
  3. Pol I transcription is linked to health, disease, and targeted therapy
    Integrated analysis of Pol I structural mechanisms, regulatory pathways, disease associations, and emerging therapeutic strategies targeting this essential eukaryotic transcriptional machinery.
  4. A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability
    Integrated analytical framework reveals 7.13-fold enrichment of doublet base substitutions at inversion breakpoints in chronic low-dose radiation exposure of human cells.