Catalytic C–H Functionalization Methods
External reference: https://openalex.org/T10354
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Trifluoromethyl copper complexes were repurposed for saccharide difluoromethylation Photo- and acid-mediated repurposing of Grushin's reagent enables efficient difluoromethylation of alcohols, saccharides, and bioactive molecules, generating antifungal leads.
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Organocatalytic CDC adds fluoronitromethane to tetrahydroisoquinolines Organocatalytic cross-dehydrogenative coupling of tetrahydroisoquinolines with fluoronitromethane using Rose Bengal and green LED irradiation for sustainable fluorinated compound synthesis.
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Photocatalysis enables synthesis of trifluoromethyl amidines and imidates Photocatalytic metal-free synthesis of α-trifluoromethyl amidines and imidates using isocyanides and trifluoroacetylsilanes, with mechanistic insights from DFT studies.
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Cyclometalated platinum products depend on the halogen in the ligand Study of cyclometalated platinum compounds formed via competing C-H and C-X bond activation pathways, with mechanistic insights from computational and spectroscopic analysis.
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Indoles converted to α-perfluoroalkylamino derivatives under mild conditions Novel sequential perfluoroalkylation and defluoroamination of indoles via sulfinate-derived radicals and HMDS-mediated C-F cleavage, yielding α-trifluoromethylated amines in up to 80% yield.