Focal Interest
Focal Interest

Cancer therapeutics and mechanisms

External reference: https://openalex.org/T11845

  1. Mycobacterial gyrase inhibition depends on DNA topology
    Study reveals that antibacterial drugs inhibit different gyrase-mediated catalytic activities at varying concentrations, with DNA topology modulating drug potency beyond DNA cleavage mechanisms.
  2. AOH1996 remained the most active PCNA inhibitor analog
    Synthesis and anticancer evaluation of PCNA inhibitor AOH1996 analogs in MCF-7 and U87 cancer cell cultures with SAR analysis and ADMET prediction
  3. Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks
    Tel1-mediated negative feedback propagates locally to reshape genome-wide meiotic DSB patterns in yeast, demonstrating how localized regulation drives emergent patterning.