Axial and Atropisomeric Chirality Synthesis
External reference: https://openalex.org/T13115
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Desymmetrization method forms N–N atropisomers with multiple stereocenters Asymmetric Michael addition constructs N-N atropisomers from indole-derived maleimides with simultaneous generation of multiple stereocenters, achieving 99% yield and exceptional stereoselectivity.
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Chiral carbon-bonding donors showed asymmetric induction Carbon-bonding donors induce asymmetric induction via noncovalent interaction, demonstrated through oxa-Pictet-Spengler cyclization with oxocarbenium intermediates.