Focal Interest
Focal Interest

Asymmetric Synthesis and Catalysis

External reference: https://openalex.org/T10013

  1. Oxoammonium catalysis enables enantioselective desymmetrization of meso-pyrrolidines
    Oxoammonium-catalyzed desymmetrization of meso-pyrrolidines via enantioselective hydride transfer with over 90% ee, featuring mechanistic insights from isolated intermediates.
  2. Organocatalytic method esterifies P(O)–OH compounds with alcohols
    Organocatalytic metal-free esterification of phosphoryl compounds with alcohols via catalytic Mitsunobu protocol, yielding phosphinate esters with broad functional group tolerance.
  3. Chiral carbon-bonding donors showed asymmetric induction
    Carbon-bonding donors induce asymmetric induction via noncovalent interaction, demonstrated through oxa-Pictet-Spengler cyclization with oxocarbenium intermediates.